Meeting Abstract

JL07. Intravenous Thiotepa for Meningeal Relapse of Breast Cancer: A Case Study

Kathryn Clarke, RN, MSN, FNP-C




  

ABSTRACT

Treatment of meningeal carcinomatosis among breast cancer patients remains a clinical challenge, with a dismal outlook for long-term survival. Intrathecal thiotepa administration has been described in the literature; however, there are practical challenges of administration into the intrathecal space, and there is no significant difference in drug exposure as measured by AUC between intravenous and intrathecal routes. One female with meningeal relapse of HER2-positive breast cancer hospitalized and felt to be preterminal was treated with IV thiotepa in 2010. Her neurologic status returned to baseline within 3 weeks, and she was felt to be in a complete radiologic and clinical remission, which continues to present day. This compelling case suggests a role for IV thiotepa in the treatment of breast cancer patients with meningeal carcinomatosis, and further study is warranted. 




For access to the full length article, please sign in.

Section Seperator
ADVERTISEMENT
Section Seperator
ADVERTISEMENT
Section Seperator
ADVERTISEMENT
Section Seperator
Copyright © 2016 Harborside Press, LLC All rights reserved.                Home | Current Issue | Previous Issue | Submissions | About JADPRO | Advertising | Privacy Policy | Contact
Copyright Notice/Disclaimer
Bot trap - Don't go here
click me