Current Issue

VOL 14 NO 6 • Sep/Oct 2023

This issue’s cover illustration depicts a cross section of the pancreas with nodules in the head and a dilated duct in the tail of the pancreas with an overlay of a family history that would lead to an increased risk of pancreatic ductal adenocarcinoma. Pancreatic ductal adenocarcinoma develops in the exocrine regions of the pancreas, commonly in the head, and is usually symptomatic in the early stages. Because of the lack of symptoms and limited screening outcomes, pancreatic cancer is often detected at later stages resulting in poorer outcomes. Artwork by Alexandra Webber © 2023, DNA Illustrations, Inc., Asheville, North Carolina.


The Importance of Endpoints in Oncology Clinical Trials


Innovative clinical trials identify appropriate endpoints when seeking to evaluate potential new cancer treatments, better ways of using existing medications, or enhanced supportive care techniques. A recent X (formerly Twitter) post highlighted a workshop held in July 2023 sponsored by the FDA, ...


Precautions for Patients Taking Tamoxifen or Aromatase Inhibitors

Mary Heery, APRN, AOCNS®, CBCN

Tamoxifen and aromatase inhibitors are widely prescribed therapies for the treatment of breast cancer. Tamoxifen is a selective estrogen receptor modulator that treats hormone-sensitive breast cancers. Research has demonstrated that tamoxifen therapy improves survival and reduces the risk of deve...

Research and Scholarship

‘My Choices, My Wishes’ Program and Its Effect on Chemotherapy at the End of Life and Advance Care Directive Documentation

Jessica Tamar Davis, DNP, AOCNP®, ACHPN

Oncology care has experienced a shift over the past decade, becoming more focused on providing goal-concordant care for seriously ill patients. The need for effective communication and clear treatment plans to match patients’ values and goals has become essential (Sanders et al., 2018). Researche...

Research and Scholarship

Patient-Reported Outcomes With Belantamab Mafodotin Treatment in Patients With Triple-Class Refractory Multiple Myeloma

Rakesh Popat,(1) BSc, MBBS, MRCP, FRCPath, PhD, Sagar Lonial,(2) MD, FACP, Peter M. Voorhees,(3) MD, Simona Degli Esposti,(4) MD, Boris Gorsh,5a PharmD, Ira Gupta,(5a) MD, Joanna Opalinska,(5) PhD, Sandhya Sapra,(5) PhD, Trisha Piontek,(5) BS, RN, Zangdong He,(5) PhD, David Kleinman,(6) MD, MBA, Debra Schaumberg,(7) SCD, OD, MPH, Antoine Regnault,(8) PhD, Juliette Meunier,(8) MSc, and Laurie Eliason,(5a) MPH

Multiple myeloma (MM) is a relapsing, incurable hematologic cancer that eventually becomes refractory to treatments. Therapies to treat relapsed/refractory MM (RRMM) aim to control disease progression, prolong survival, reduce disease-related symptoms, and optimize health-related quality of life ...

Review Article

Post-Transplant Cyclophosphamide for the Prevention of Graft-vs.-Host Disease in Allogeneic Hematopoietic Cell Transplantation: A Guide to Management for the Advanced Practitioner

Ekaterina Kachur, PharmD, BCOP, Jai N. Patel, PharmD, BCOP, CPP, Allison L. Morse, PharmD, BCOP, Donald C. Moore, PharmD, BCPS, BCOP, DPLA, FCCP, and Justin R. Arnall, PharmD, BCOP

Since its first US Food and Drug Administration (FDA) approval in 1959, cyclophosphamide use has expanded to solid and hematologic malignancies, autoimmune diseases, and mobilization and conditioning regimens for hematopoietic cell transplantation (HCT). More recently, cyclophosphamide has emerge...

Review Article

Pancreatic Cancer and the Family Connection: The Role of Advanced Practitioners in Screening and Educating Genetically At-Risk Individuals

Tracy Lowe,(1) PhD, MS, RN, Jane DeLuca,1 PhD, MS, RN, CPNP-PC, Ludovico Abenavoli,(2) MD, PhD, MSc, and Luigi Boccuto,(1) MD

Pancreatic cancer is one of the deadliest cancers in the United States, accounting for 8% of cancer deaths each year. It is surpassed only by lung cancer (23%) and colorectal cancer (9%) in terms of causes of cancer deaths annually (Centers for Disease Control and Prevention [CDC], 2022). Pancrea...

Grand Rounds

Surgical Management of Gastrointestinal Stromal Tumors

Heather Townsend, MPAP, PA-C

Case Study SY is an 86-year-old female who presented to the emergency department with an initial complaint of dizziness, fatigue, and generalized weakness over the past several days. Past medical history is significant for hyperlipidemia and esophagitis with esophageal structuring. Previous surgi...

Diagnostic Snapshot

Knowing Your Target: Altered Mental Status From an Unsuspected Source

Sarah Hemstetter, MSN, CRNP, AOCNP®

History and Chief Complaint KS is a 52-year-old female with a history of chronic kidney disease, hypertension, and relapsed IgG kappa multiple myeloma who is postautologous stem cell transplant and receiving therapy with daratumumab (Darzalex), lenalidomide, dexamethasone, and denosumab. KS prese...

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