Current Issue
VOL 12 NO 1 • JAN/FEB 2021
This issue’s cover illustration depicts how a BCL-2 inhibitor binds to BCL-2 proteins releasing pro-apoptotic proteins that initiate programmed cell death by activation of caspases via the apoptosome. Artwork by Alexandra Webber Baker © 2021, DNA Illustrations, Inc., Asheville, North Carolina.EditorialBeth Faiman, PhD, MSN, APRN-BC, AOCN®, FAANEvery new year brings a time for reflection and optimism for what lies ahead. In December 2020, two newly approved mRNA vaccines were approved—BNT162b2 mRNA Covid-19 vaccine (BioNTech/Pfizer) and mRNA-1273 (Moderna/NIAID)—to protect individuals against severe acute respiratory syndrome coronaviru...
Research and ScholarshipLauren M. Garner, PharmD, BCPPS, Theresa Kline, PharmD, BCPS, BCCP, Jordan Miller, PharmD, BCOP, CPP, Allison Deal, MS, Anqi Zhu, MS, PhD(c), Margaret R. Sketch, PharmD, MPH, Catherine C. Coombs, MD, and Benyam Muluneh, PharmD, BCOP, CPPChronic lymphocytic leukemia (CLL) is a B-cell neoplasm characterized by clonal expansion of small lymphocytes that are primarily found in the blood and bone marrow with varying involvement of lymph nodes, the liver, and the spleen. This B-cell malignancy is usually slow growing, with many patien...
Research and ScholarshipLori A. Seaborne, MPAS, PA-C, Megan Peterson, DNP, David M. Kushner, MD, Janelle Sobecki, MD, MA, and Joanne K. Rash, MPAS, PA-CAdvanced practitioners (APs) are an increasingly valuable part of the care team in oncology settings. They are being utilized to provide a wide variety of services, including managing acute outpatient issues, prescribing chemotherapy, rounding on inpatients, and assisting in surgery (Corcoran, Du...
Review ArticleTaCharra Y. D. Woodard, MSN, APRN, ACNP-BC, AOCNP®, Carla M. Patel, MSN, APRN, ACNP-BC, and Garrett L. Walsh, MDThe Enhanced Recovery Program (ERP) is a comprehensive, multidisciplinary approach that directly impacts the functional recovery and quality of life of patients after surgery. The evidence-based interventions throughout each phase of the perioperative journey synergistically work to improve the p...
Continuing EducationAdvanced Practice Perspectives on Preventing and Managing Tumor Lysis Syndrome and Neutropenia in Chronic Lymphocytic Leukemia
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Grand RoundsAmy Goodrich, RN, MSN, CRNP Tumor lysis syndrome (TLS) is an oncologic emergency caused by the rapid release of intracellular contents of tumor cells into the peripheral blood, although it may also occur spontaneously. Laboratory TLS is characterized by hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia. In la...
Grand RoundsAmanda M. Marinova, MS, PA-C, Jennifer L. Reilly, CRNP, BSN, MSN, RN, AANP, Victoria Wong, MS, PA-C, Stephanie Weiss, MD, and Anthony J. Olszanski, MD Case Study
In 2012, a 43-year-old female underwent an excisional biopsy of a mole that was present on her posterior trunk, near her midline. The pathology report was consistent with an ulcerated 2.9 mm malignant melanoma. She underwent a wide local excision and sentinel lymph node mapping. In th...
Practice MattersPoonam Goswami, DNP, FNP-C, AOCNP®The 2014 Institute of Medicine report, Dying in America: Improving Quality and Honoring Individual Preferences Near the End of Life, identified an urgent need for improvement in health care at the end of life. To improve care at the end of life, providers and patients must engage sooner in conver...
Prescriber's CornerKristina F. Byers, PharmD, BCOPBreast cancer is the most commonly diagnosed cancer in the United States, accounting for 30% of all new cancer diagnoses annually. It is estimated that 279,100 people were diagnosed with breast cancer in 2020. Although the development of newer therapies and better screening methods has increased ...
Diagnostic SnapshotDietrich Davis, FNP-BC, and Steven H. Wei, MS, MPH, PA-C, DFAAPAHistory
Ms. BP is a 38-year-old female with a past medical history significant for multiple sclerosis who has been receiving high-dose glucocorticoids and rituximab (Rituxan) treatments for the past 12 years. For the past couple of years, she has been followed by a gastroenterologist for symptom...
