Current Issue

VOL 9 • NO 2 MAR 2018


Chemotherapy-Induced Nausea and Vomiting: Updates and Recommendations

Pamela Hallquist Viale, RN, MS, CNS, ANP

Chemotherapy-induced nausea and vomiting (CINV) has remained a much-feared side effect of cancer therapy. Few pharmaceutical choices were available 35 years ago when I started practice, and when the first serotonin antagonist 5-hydroxytryptamine-3 (5-HT3) was approved in the late 1980s and brough...


Cardio-oncology: A Subspecialty in its Infancy

Jessica Shank Coviello, DNP, APRN, ANP-BC

Several years ago, after spending my professional life in cardiology, I was happy to join a private practice where I could focus my energies on managing patients with heart failure (HF). It was through this experience that I noticed a growing population of women previously treated for breast canc...

Review Article

Cardiovascular and Cancer Risk: The Role of Cardio-oncology

Jessica Shank Coviello, DNP, APRN, ANP-BC

Heart disease and cancer, although seen as two distinct diseases, have significant commonalities, including risk factors, genetic, metabolic, and inflammatory components, and shared preventative strategies. Together, they represent the most common cause of death in the United States (Curigliano e...

Review Article

Acute Promyelocytic Leukemia: A Summary

Meaghan M. Ryan, MSN, FNP-BC

Acute promyelocytic leukemia (APL) is a rare subtype of acute myeloid leukemia, which historically had been considered one of the most fatal types of this disease process. With advances in treatment regimens, namely the introduction of all-trans retinoic acid (ATRA), outcomes have drastically imp...

Review Article

Drug-Drug Interactions, Safety, and Pharmacokinetics of EGFR Tyrosine Kinase Inhibitors for the Treatment of Non–Small Cell Lung Cancer

Colleen R. Kucharczuk,(1) DNP, CRNP, Alex Ganetsky,(1) PharmD, BCOP, and J. Michael Vozniak,(2) PharmD, BCOP

The identification of activating mutations in the epidermal growth factor receptor (EGFR) has expanded treatment options for non–small cell lung cancer (NSCLC), where the presence of these mutations can sensitize tumors to EGFR inhibitors (Rosell et al., 2010). For patients whose tumors have sens...

Original Research

Addressing the Symptom Management Gap in Patients With Cancer and Heart Failure Using the Interactive Voice Response System: A Pilot Study

Anecita P. Fadol,(1) PhD, FNP-BC, FAANP, Tito R. Mendoza,(2) PhD, Daniel J. Lenihan,(3) MD, and Donna L. Berry,(4) PhD, RN, AOCN®, FAAN

Symptom management in patients with cancer and concurrent heart failure (HF) presents a major challenge to patients, families, and health-care providers throughout the entire trajectory of the disease process (Fadol et al., 2008). In the general population, HF diagnosis is borne by individuals ag...

Grand Rounds

Paraneoplastic Encephalopathy in a Patient With Metastatic Lung Cancer: A Case Study

Scott M. Rowley, MS, CNP, ANP-BC, AOCNP®

Paraneoplastic syndromes are a group of disorders that are associated with malignant diseases (cancers) but are not directly related to the physical effects of the primary or metastatic tumors (Kanaji et al., 2014). The term “paraneoplastic” was coined in the 1940s; however, paraneoplastic condit...

Practice Matters

Joining Forces: Establishing a Cardio-oncology Clinic

Caroline Austin-Mattison, DNP

The survival rate of patients with cancer has increased over the past 25 years in the United States. The 5-year relative survival rate of patients diagnosed with cancer between the years 1975 and 1977 was 49% for all cancer sites, and this number improved to 68% between 2004 and 2010. When assess...

Practice Matters

An Anecdotal Outpatient Approach to Caring for Patients With End-Stage Hematologic Malignancies

Mark Honor, PA-C

I have been managing patients with hematologic malignancies for over 10 years at the H. Lee Moffitt Cancer Center in Tampa. I spent the first 7 years in the stem cell transplant department, and more than 3 years ago I started working at a satellite location to our main hospital in the capacity of...

Prescriber's Corner

Olaratumab: A New Strategy in the Treatment of Advanced Soft-Tissue Sarcoma

Donald C. Moore, PharmD, BCPS, BCOP, DPLA, and Lesli A. Lavery, PharmD, BCOP

Sarcomas represent a heterogeneous group of mesenchymal malignancies that may arise in the soft tissue or bone (Skubitz et al., 2007). Soft-tissue sarcomas (STS) comprise less than 1% of all cancer diagnoses. About 80% of sarcoma cases in adults are STS (Siegel, Miller, & Jemal, 2018). It is ...

Diagnostic Snapshot

Diagnostic Snapshot: "I Have a Bad Cold"

Julie Kay Baker,(1) APRN, and Virginia L. Beggs,(2) MSc, APRN, CHFN

Ms. J is a 37-year-old woman with a history of Hodgkin lymphoma, presenting with symptoms due to mediastinal adenopathy, diagnosed at age 12. She was treated with vincristine, prednisone, procarbazine, and doxorubicin, then 21 Gy radiation to the mediastinum. At 36, she was diagnosed with locally...



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