Grand Rounds
Management of Advanced Prostate Cancer With Relugolix: Illustrative Case Scenarios From an Advanced Practice Provider Perspective
Jared Thorley,(1) APRN, MSN, FNP, and Saneese Stephen,(2) MPAS, PA-C, MPA
From (1)Intermountain Healthcare, Salt Lake City, Utah; (2)University of Texas MD Anderson Cancer Center, Houston, Texas
Authors’ disclosures of conflicts of interest are found at the end of this article.
Correspondence to: Jared Thorley, APRN, MSN, FNP, Intermountain Medical Center,
5171 S. Cottonwood Street, Murray, UT 84107
E-mail: jared.thorley@imail.org
J Adv Pract Oncol 2024;15(1):43–55 |
https://doi.org/10.6004/jadpro.2024.15.1.5 |
© 2024 BroadcastMed LLC
ABSTRACT
Prostate cancer is the second most common cause of cancer-related mortality among men in the United States, with an estimated 34,700 deaths annually. Androgen deprivation therapy (ADT) is the cornerstone of advanced prostate cancer therapy, and injectable luteinizing hormone-releasing hormone (LHRH) agonists have served as the most commonly used ADT for over 30 years. Relugolix, a first-in-class, once-daily, oral gonadotropin-releasing hormone (GnRH) antagonist, was developed to address some of the limitations of available ADT therapies. Herein, we present two hypothetical case reports via an advanced practice provider (APP) perspective that reflect prototypical examples of patients with advanced localized disease not suitable for surgery or newly diagnosed hormone-sensitive metastatic disease treated with relugolix. The cases presented are meant to be instructional and within the scope of the current approved prescribing information for all medications mentioned. Best practices from an APP perspective are shared.
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