Thromboses and Hemorrhages are Common in MPN Patients with High JAK2V617F Allele Burden

The most common causes of morbidity and mortality in patients with myeloproliferative neoplasms (MPNs) are thrombotic and hemorrhagic complications. The JAK2V617F mutation, commonly found in MPNs, correlates with several clinical and laboratory characteristics even if the relevance of JAK2V617F allele burden in the natural history of these diseases is unclear. The researchers in this study suggest that patients with MPNs with JAK2V617F allele burden higher than 75% should be considered high-risk patients, being prone to develop thrombo-hemorrhagic complications during the course of the disease.

 Ann Hematol

By continuing to browse this site you permit us and our partners to place identification cookies on your browser and agree to our use of cookies to identify you for marketing. Read our Privacy Policy to learn more.