Researchers Discover Key to Drug Resistance in Common Breast Cancer Treatment

Scientists from the Florida campus of The Scripps Research Institute, the University of California, San Diego, and the University of Illinois have found that two immune system molecules (interleukin 1 beta and tumor necrosis factor alpha) may be key to the development of drug resistance in estrogen-driven breast cancers. The researchers believe this finding may open the door to novel therapeutic approaches and influence treatment decisions.

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Perspectives on the Collaborative Management of HER2-Positive Breast Cancer

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In The News

The ASCO Post

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Age and Subtype Impact Outcomes More Than Surgical Extent in Breast Cancer

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Neoadjuvant Therapy Fundamental in Triple-Negative and HER2-Positive Breast Cancer

BreastCancer.org

Kisqali Approved by FDA to Treat Hormone-Receptor-Positive, Advanced-Stage Disease

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In Patients With Diabetes, Metformin is Linked to Improved Outcomes in Patients With HER2-Positive, Hormone-Receptor-Positive Breast Cancer

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In The Literature

JAMA Oncol

Adjuvant Capecitabine in Combination With Docetaxel, Epirubicin, and Cyclophosphamide for Early Breast Cancer: The Randomized Clinical FinXX Trial

Eur J Cancer

Long-term Outcome of the REMAGUS 02 Trial, a Multicenter Randomised Phase II Trial in Locally Advanced Breast Cancer Patients Treated With Neoadjuvant Chemotherapy With or Without Celecoxib or Trastuzumab According to HER2 Status

BMJ Open

Efficacy and Safety of Lapatinib and Trastuzumab for HER2-Positive Breast Cancer: a Systematic Review and Meta-Analysis of Randomised Controlled Trials

JAMA Oncol

Brain Metastases in Newly Diagnosed Breast Cancer: A Population-Based Study

BMC Cancer

Development of a Test that Measures Real-Time HER2 Signaling Function in Live Breast Cancer Cell Lines and Primary Cells

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