The REMAGUS-02 multicenter randomized phase II trial showed that the addition to neoadjuvant chemotherapy of trastuzumab in patients with localized HER2-positive breast cancer increased the pathological complete response rate and that the addition of celecoxib in HER2-negative cases did not increase the pathological complete response rate. This article the long-term follow-up results for disease-free survival and overall survival, indicating that celecoxib combined with neoadjuvant chemotherapy provided neither pathological complete response rate benefit nor survival benefit in patients with HER2-negative breast cancer.
Eur J Cancer