Prescriber's Corner

Inotuzumab Ozogamicin in Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia

Sherry Williams, PharmD, BCOP, and Miryoung Kim, PharmD, BCOP

The Arthur G James Cancer Hospital and Solove Research Institute, Columbus, Ohio

Authors’ disclosures of conflicts of interest are found at the end of this article.

Sherry Williams, PharmD, BCOP, 5841 S. Maryland Ave MC0010, Chicago, IL 60637. E-mail: sherry.williams@uchospitals.edu


J Adv Pract Oncol 2018;9(6):670–676 | https://doi.org/10.6004/jadpro.2018.9.6.9 | © 2018 Harborside™


  

ABSTRACT

Abstract

Despite initial complete remission rates of up to 90%, long-term, disease-free survival remains poor in patients with newly diagnosed acute lymphoblastic leukemia (ALL). Response to salvage chemotherapy is suboptimal; therefore, novel therapeutic agents are being investigated in order to improve outcomes in these patients. Inotuzumab ozogamicin is a CD22-directed antibody-drug conjugate recently approved by the US Food and Drug Administration for the treatment of adults with relapsed or refractory B-cell precursor ALL. Inotuzumab ozogamicin improves response rate, minimal residual disease negativity, and survival compared to standard chemotherapy in this population. In addition, it offers more opportunities to proceed to an allogeneic stem cell transplant in patients who otherwise may not be candidates.




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