Neratinib for Extended Anti-HER2 Therapy in Early Breast Cancer
Presented by G. Thomas Budd,(1) MD, and Wendy H. Vogel,(2) MSN, FNP, AOCNP®
1)Taussig Cancer Center at Cleveland Clinic, Cleveland, Ohio; 2)Wellmont Cancer Institute, Kingsport, Tennessee
Presenters’ disclosures of conflicts of interest are found at the end of this article.
J Adv Pract Oncol 2018;9(3):298–302 |
© 2018 Harborside™
Neratinib following the completion of trastuzumab has been shown to reduce the risk of disease recurrence for patients with HER2-positive early breast cancer in whom extended adjuvant therapy seems advisable. In clinical trials, the most common side effect of neratinib and other anti-HER2 therapies was diarrhea. Presenters at JADPRO Live clarified the findings of trials studying the benefit of differing prophylactic regimens with loperamide, budesonide, and colestipol.
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