Practice Matters

Basic Review of the Cytochrome P450 System

Anne M. McDonnell, PharmD, BCOP, and Cathyyen H. Dang, PharmD, BCPS

From Brigham and Women’s Hospital, Boston, Massachusetts, and Froedtert & The Medical College of Wisconsin, Milwaukee, Wisconsin

The authors have no conflicts of interest to disclose.

Correspondence to: Anne M. McDonnell, PharmD, BCOP, Brigham and Women’s Hospital, Department of Pharmacy, 75 Francis Street, L2, Boston, MA 02115. E-mail: amcdonnell@partners.org


J Adv Pract Oncol 2013;4:263–268 | DOI: 10.6004/jadpro.2013.4.4.7 | © 2013 Harborside Press®


  

ABSTRACT

Cytochrome P450 (CYP) is a hemeprotein that plays a key role in the metabolism of drugs and other xenobiotics. Understanding the CYP system is essential for advanced practitioners, as the consequences of drug-drug interactions can be profound. This article provides a primer on the CYP system, its potential for drug interactions, and the genetic polymorphisms that can exist in hematology/oncology patients.




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