Grand Rounds

Richter Transformation: Clinical Manifestations, Evaluation, and Management

Melanie Douglas, MS, PA-C

From Memorial Sloan Kettering Cancer Center, New York, New York

Author’s disclosure of conflict of interest is found at the end of this article.

Correspondence to: Melanie Douglas, MS, PA-C, 1275 York Avenue, New York, NY 10065 E-mail: douglasm@mskcc.org


J Adv Pract Oncol 2022;13(5):525–534 | https://doi.org/10.6004/jadpro.2022.13.5.6 | © 2022 Harborside™


  

ABSTRACT

Richter transformation is a devastating and rare but not uncommon development of an aggressive B-cell lymphoma in patients with chronic lymphocytic leukemia or small lymphocytic lymphoma. Prognosis is dismal, with survival generally in the realm of months to a couple of years. Many patients progress quickly after traditional first-line immunochemotherapy. Nonetheless, novel therapies are on the horizon. It is important that the advanced practitioner have awareness and knowledge of this condition in order to furnish a crucial timely diagnosis and to provide appropriate treatment. 




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