Grand Rounds
Richter Transformation: Clinical Manifestations, Evaluation, and Management
Melanie Douglas, MS, PA-C
From Memorial Sloan Kettering Cancer Center, New York, New York
Author’s disclosure of conflict of interest is found at the end of this article.
Correspondence to: Melanie Douglas, MS, PA-C, 1275 York Avenue, New York, NY 10065
E-mail: douglasm@mskcc.org
J Adv Pract Oncol 2022;13(5):525–534 |
https://doi.org/10.6004/jadpro.2022.13.5.6 |
© 2022 Harborside™
ABSTRACT
Richter transformation is a devastating and rare but not uncommon development of an aggressive B-cell lymphoma in patients with chronic lymphocytic leukemia or small lymphocytic lymphoma. Prognosis is dismal, with survival generally in the realm of months to a couple of years. Many patients progress quickly after traditional first-line immunochemotherapy. Nonetheless, novel therapies are on the horizon. It is important that the advanced practitioner have awareness and knowledge of this condition in order to furnish a crucial timely diagnosis and to provide appropriate treatment.
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