Prescriber's Corner

Encorafenib and Binimetinib Combination Therapy in Metastatic Melanoma

Jessica Davis,(1) PharmD, BCOP, CPP, and Megan Wayman,(2) PharmD

From (1)Levine Cancer Institute, Charlotte, North Carolina; (2)Carolinas Medical Center, Charlotte, North Carolina

Authors’ disclosures of conflicts of interest are found at the end of this article.

Correspondence to: Jessica Davis, PharmD, BCOP, CPP, 1021 Morehead Medical Drive, Charlotte, NC 28204. E-mail: jessica.m.davis@atriumhealth.org


J Adv Pract Oncol 2022;13(4):450–455 | https://doi.org/10.6004/jadpro.2022.13.4.7 | © 2022 Harborside™


  

ABSTRACT

The treatment landscape for metastatic melanoma has changed dramatically over the past few years as new medications have been developed. Encorafenib, a B-Raf protein kinase inhibitor, and binimetinib, a MEK inhibitor, were approved by the U.S. Food and Drug Administration in 2018 for the treatment of patients with unresectable or metastatic melanoma which harbor a BRAF V600E or V600K mutation. These approvals were based on findings from the COLUMBUS trial, which demonstrated improvement in progression-free survival and overall survival with the combination of encorafenib plus binimetinib compared with vemurafenib alone. Encorafenib plus binimetinib is the third BRAF plus MEK inhibitor combination to be approved, and there are clinical and practical differences between the combination regimens that should be considered when selecting an appropriate treatment regimen for patients.




For access to the full length article, please sign in.

Section Seperator
ADVERTISEMENT
Section Seperator
ADVERTISEMENT
Section Seperator
ADVERTISEMENT
Section Seperator
Copyright © 2010-2022 Harborside Press, LLC All rights reserved.               
Home | Current Issue | Previous Issue | Submissions | About JADPRO | Advertising | Privacy Policy | Contact | Copyright Notice/Disclaimer | Subscribe
Bot trap - Don't go here
By continuing to browse this site you permit us and our partners to place identification cookies on your browser and agree to our use of cookies to identify you for marketing. Read our Privacy Policy to learn more.