Mogamulizumab-kpkc: A Novel Therapy for the Treatment of Cutaneous T-Cell Lymphoma
Sutton Watson,(1) PharmD, and Justin Bradley Marx,(2) PharmD, BCPS
(1) University of Tennessee Medical Center, Knoxville, Tennessee; (2) Prisma Health Upstate – Cancer Institute, Greenville, South Carolina
Authors’ disclosures of conflicts of interest are found at the end of this article.
Justin Bradley Marx, PharmD, BCPS, Prisma Health Upstate – Cancer Institute, 3 Butternut Drive, Suite B, Greenville, SC 29605. E-mail: email@example.com
J Adv Pract Oncol 2019;10(8):883–888 |
© 2019 Harborside™
Mogamulizumab-kpkc provides a novel mechanism of action for the treatment of mycosis fungoides and Sézary syndrome. The efficacy and safety of mogamulizumab-kpkc for the treatment of relapsed or refractory mycosis fungoides and Sézary syndrome were demonstrated in a multicenter, open-label, randomized phase III trial comparing mogamulizumab-kpkc with vorinostat. Patients treated with mogamulizumab-kpkc showed a statistically significant increased progression-free survival (PFS; 7.7 months) compared with vorinostat (3.1 months). Overall response rates were higher with mogamulizumab-kpkc compared with vorinostat (28% vs. 5%; p < .0001). The most common adverse events (> 20%) associated with mogamulizumab-kpkc include rash, infusion-related reaction, fatigue, diarrhea, musculoskeletal pain, and upper respiratory tract infection. The use of mogamulizumab-kpkc up to 50 days prior to allogeneic hematopoietic stem cell transplantation has been associated with an increased risk of severe acute graft-vs.-host disease, steroid-refractory graft-vs.-host disease, and mortality. Additional labeled warnings include dermatologic toxicity, infection, and autoimmune complications. The overall benefit to risk assessment of mogamulizumab-kpkc is acceptable, but its use is constrained by the high cost of treatment and the short-term benefit.
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