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Amber Koehler, MPAS, PA-C, of Mayo Clinic, summarizes key points from an abstract she presented at the ASH Annual Meeting. This study, which spanned over 18 years, examined how initial management strategy (watch and wait vs. treatment) at diagnosis impacted patient-reported outcomes in CLL survivors, and how these outcomes differed between the eras of chemoimmunotherapy and targeted agents (Abstract 498).