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Lisa Nodzon, PhD, ARNP, AOCNP, of the H. Lee Moffitt Cancer Center & Research Institute, discusses an update on treating Richter Syndrome, including information on clonally related vs unrelated variants of the disease; the role of venetoclax, acalabrutinib, pirtobrutinib, and DA-EPOCH-VR chemotherapy; and the use of immune checkpoint inhibitors and CAR T-cell therapy; as well as a number of ongoing clinical trials on combinations of various targeted agents.