Current Issue

VOL 9 • NO 4 MAY/JUN 2018


Breast Cancer and Body Image Issues

Pamela Hallquist Viale, RN, MS, CNS, ANP

Breast cancer remains a common malignancy, with an estimated 366,120 new cases expected in women in the United States this year (, 2018). Although the incidence rate for this disease has decreased since the year 2000, the disease remains deadly for some: Approximately 40,920 women...

Original Research

Feasibility of Outpatient High-Dose Methotrexate Infusions in Pediatric Patients With B-Lineage Acute Lymphoblastic Leukemia

Joy L. Bartholomew, APRN, Hongying Dai, PhD, Keith J. August, MD, MS, Robin E. Ryan, MPH, and Kristin A. Stegenga, PhD, RN, CPON

Acute lymphoblastic leukemia (ALL), the most common form of pediatric leukemia, accounts for 26% of all cancers occurring in children from birth to 14 years of age (Ward, DeSantis, Robbins, Kohler, & Jemal, 2014). Of the 3,000 new pediatric cases arising each year in the United States (Ries e...

Review Article

Iron Overload in Myelodysplastic Syndromes: Pathophysiology, Consequences, Diagnosis, and Treatment

Lindsey Lyle, MS, PA-C, and Alex Hirose, MMS, PA-C

Myelodysplastic syndromes (MDS) encompass a heterogeneous group of hematologic malignancies that are characterized by ineffective hematopoiesis and risk for progression to acute myeloid leukemia (AML; Mitchell, Gore, & Zeidan, 2013; Petrou et al., 2015; Shah, Kurtin, Arnold, Lindroos-Kolqvist...

Review Article

Management of Advanced Bladder Cancer: An Update

Emily A. Lemke, DNP, AGPCNP-BC, AOCNP®, and Amishi Yogesh Shah, MD

Bladder cancer is the sixth most common malignancy in the United States, with 81,190 new cases and 17,240 deaths from bladder cancer predicted in 2018 (American Cancer Society, 2018). The most common presenting symptom is hematuria, although dysuria, frequency, and urgency occur in a certain subs...

Grand Rounds

Clinical Management of Pneumonitis in Patients Receiving Anti–PD-1/PD-L1 Therapy

Justin E. Bala-Hampton, DNP, MPH, RN, AGACNP-BC, AOCNP®, Angela F. Bazzell, DNP, RN, FNP-BC, AOCNP®, and Joyce E. Dains, DrPH, JD, RN, FNP-BC, FNAP, FAANP

Immune checkpoint blockade monoclonal antibodies have revolutionized treatment and improved the prognosis for many patients with cancer (Eigentler et al., 2016; Weber, Yang, Atkins, & Disis, 2015; Wu, Hong, Zhang, Lu, & Miao, 2017). Immunotherapeutic drugs approved by the US Food and Drug...

Practice Matters

An Oncology NP-MD Partnership: Challenges and Rewards

Catherine S. Bishop, DNP, NP, AOCNP®

The 2017 State of Cancer Care in America report by the American Society of Clinical Oncology highlights progress and opportunities in the ever-changing and challenging specialty of oncology. According to the report, the number of cancer survivors is predicted to reach 20.3 million by 2026. This i...

Prescriber's Corner

Enasidenib: An Oral IDH2 Inhibitor for the Treatment of Acute Myeloid Leukemia

Rebecca A. Myers,(1) PharmD, Scott Wirth,(2) PharmD, BCOP, Sherry Williams,(3) PharmD, BCOP, and Patrick J. Kiel,(1,4) PharmD, BCPS, BCOP

Acute myeloid leukemia (AML) is characterized by infiltration of the bone marrow, blood, and other tissues by proliferative, clonal, abnormally differentiated, and occasionally poorly differentiated cells of the hematopoietic system. The incidence of AML has increased from 3.4 per 100,000 individ...

Diagnostic Snapshot

Obstructive Dysphagia and Positional Dyspnea: Can You Identify the Cause?

Kimberly Dotter, APRN, MD

History Mr. V is a 25-year-old man with no significant past medical history who began experiencing shortness of breath while lying supine, along with changes in swallowing over the past several months. More recently, he noted a neck mass while shaving. Mr. V presented to clinic with complaints of...



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