Current Issue

VOL 10 NO 7 • SEP/OCT 2019

This issue’s cover illustration depicts the mechanism of action of duvelisib, an oral δ and γ PI3K inhibitor. This dual isoform blockade inhibits the growth and proliferation of malignant B cells and decreases recruitment of support cells within the tumor microenvironment. Blocking the PI3Kδ pathway prevents the growth and survival of malignant B cells, while blocking PI3Kγ affects the recruitment and differentiation of the cells that support the growth and survival of malignant B cells, such as CD4+ T cells and tumor-associated macrophages. Artwork by Alexandra Webber Baker © 2019, DNA Illustrations, Inc., Asheville, North Carolina.


Timely Assessment and Management of Febrile Neutropenia

Pamela Hallquist Viale, RN, MS, CNS, ANP

It’s almost time for JADPRO Live in Seattle this October. The meeting promises to be another packed 4 days of focused and relevant education for the advanced practitioner (AP). I hope to see you there! Management of Febrile Neutropenia Assessment and management of patients experiencing an oncolog...

Quality Improvement

Long-Acting Somatostatin Analogue Safety Monitoring Protocol for Outpatients With Neuroendocrine Tumors

Jordan Gabrielsen,(1) PharmD, Gianna Girone,(1) PharmD, Bonita Bennett,(2) BSN, and Anna Jung,(2) PharmD, BCPS

Long-acting formulations of somatostatin analogues (SSAs) that are approved for use include octreotide (Sandostatin LAR Depot, Novartis Pharmaceuticals Corporation, 2019a; Sandostatin LAR, Novartis Pharmaceuticals UK Ltd, 2018a), lanreotide (Somatuline Depot, Ipsen Biopharmaceuticals, Inc, 2019; ...

Quality Improvement

Implementation of a Survivorship Care Plan Program in a Community-Based Oncology Clinic

Stephanie L. Soulia,(1) DNP, RN, ANP-BC, Elizabeth A. Duffy,(2) DNP, RN, CPNP, Kimberly A. Morley,(3) MD, and Ellen M. L. Smith,(2) PhD, APRN, AOCN®, FAAN

Fourteen million cancer survivors are living in the United States today. Due to improved early detection and treatment, this number is expected to double by 2030 (Centers for Disease Control and Prevention, 2016). This increased survival brings its own challenges: Survivors need preparation to tr...

Review Article

Aztreonam and Vancomycin for Initial Treatment of Febrile Neutropenia in Penicillin-Allergic Patients During Hematopoietic Stem Cell Transplantation

Steven Trifilio, RPh, and Jayesh Mehta, MD

Infections that occur during episodes of neutropenic fever (NF) in patients who undergo hematopoietic stem cell transplantation (HSCT) can cause serious morbidity and mortality. Guidelines suggest initiating antibiotic coverage with a broad-spectrum β-lactam antibiotic as the backbone for initial...

Grand Rounds

Treatment of Pregnancy-Associated Breast Cancer

Bernadette Labriola, RN, MSN, FNP-C

Breast cancer is the second most common cancer diagnosis during pregnancy (Shachar et al., 2017). It occurs in approximately 0.2% to 2.6% of all woman diagnosed with cancer (Shachar et al., 2017). Cervical cancer during pregnancy is the most common cancer diagnosis during pregnancy (Shachar et al...

Practice Matters

Oncology Couples’ Retreats: A Focus on Relationships Between Patients and Their Caregivers

Amy Hacker-Prietz, PA-C, Eden Stotsky-Himelfarb, BSN, RN, Beth Kozak Onners, RN, MS, CCRN, OCN®, and Janet Street

In addition to the physical health concerns that a cancer diagnosis brings, a wide spectrum of psychosocial concerns also accompanies a diagnosis. These psychosocial concerns affect not only the patient, but also the family and caregiver, and often to a greater extent. Some oncology patients are ...

Prescriber's Corner

A Review of PI3K Inhibitors in B-Cell Malignancies

Laura Cannon,(1) PharmD, MPH, Emmeline C. Academia,(2) PharmD, and Ashley E. Glode,(2) PharmD, BCOP

Activation of the phosphoinositide 3-kinase (PI3K) pathway has become an area of interest in cancer pathophysiology and drug development. The PI3K pathway plays a primary role in cell signaling and cellular responses such as proliferation and metabolism, and overexpression of PI3K isoforms may be...

Prescriber's Corner

Letermovir for Cytomegalovirus Prevention in Patients Undergoing Hematopoietic Cell Transplantation

Kori Daniels, PharmD, and Amber Clemmons, PharmD, BCOP

Cytomegalovirus (CMV) is a ubiquitous double-stranded DNA herpes virus that infects over 50% of adults by age 40 (Bhat, Joshi, Sarode, & Chavan, 2015). Transmission most commonly occurs through direct contact with bodily fluids (e.g., saliva or urine), sexual contact, perinatally (in utero, t...

Diagnostic Snapshot

Diagnostic Snapshot: What Caused This Left Renal Infiltrate in a Young, Healthy Woman?

Elizabeth Wolf, PA-C

HISTORY VD is a 44-year-old female who presented on July 10, 2018, to the Urology clinic with a left renal pelvis lesion. She initially had an episode of abdominal pain on March 29, 2018, that prompted a CT scan of the abdomen and pelvis. The CT showed an abnormality in the left upper pole with c...

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