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Design and Synthesis of Janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) Bispecific Inhibitors Based on Pacritinib and Evidence of Dual Pathway Inhibition in Hematological Cell Lines

This study provides new tool compounds for further exploration of dual JAK-HDAC pathway inhibition achieved with a single molecule.

 Journal of Medicinal Chemistry