Vinorelbine With Pertuzumab and Trastuzumab as First-Line Treatment in Patients With HER2-Positive Breast Cancer

Pertuzumab and trastuzumab given with a taxane is recommended by NCCN guidelines for the first-line treatment of patients with HER2-positive metastatic breast cancer. This recommendation is largely based on the CLEOPATRA study, which demonstrated a PFS and OS advantage to adding pertuzumab.

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Perspectives on the Collaborative Management of HER2-Positive Breast Cancer

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In The News

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Neoadjuvant Therapy Fundamental in Triple-Negative and HER2-Positive Breast Cancer

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In The Literature

JAMA Oncol

Adjuvant Capecitabine in Combination With Docetaxel, Epirubicin, and Cyclophosphamide for Early Breast Cancer: The Randomized Clinical FinXX Trial

Eur J Cancer

Long-term Outcome of the REMAGUS 02 Trial, a Multicenter Randomised Phase II Trial in Locally Advanced Breast Cancer Patients Treated With Neoadjuvant Chemotherapy With or Without Celecoxib or Trastuzumab According to HER2 Status

BMJ Open

Efficacy and Safety of Lapatinib and Trastuzumab for HER2-Positive Breast Cancer: a Systematic Review and Meta-Analysis of Randomised Controlled Trials

JAMA Oncol

Brain Metastases in Newly Diagnosed Breast Cancer: A Population-Based Study

BMC Cancer

Development of a Test that Measures Real-Time HER2 Signaling Function in Live Breast Cancer Cell Lines and Primary Cells

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