In HER2-Negative Breast Cancer, Brain Mets Are HER2-Positive 20% of the Time

The finding that a patient with HER2-negative breast cancer can have brain metastases that are HER2-positive warrants "immediate clinical attention," say researchers who found this was the case in one in five patients in a small, unique study. Immediate steps are needed because such patients could benefit from a HER-targeted therapy but will not receive one because they tested HER2 negative for the primary breast cancer, they point out.

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Perspectives on the Collaborative Management of HER2-Positive Breast Cancer

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In The News

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In The Literature

JAMA Oncol

Adjuvant Capecitabine in Combination With Docetaxel, Epirubicin, and Cyclophosphamide for Early Breast Cancer: The Randomized Clinical FinXX Trial

Eur J Cancer

Long-term Outcome of the REMAGUS 02 Trial, a Multicenter Randomised Phase II Trial in Locally Advanced Breast Cancer Patients Treated With Neoadjuvant Chemotherapy With or Without Celecoxib or Trastuzumab According to HER2 Status

BMJ Open

Efficacy and Safety of Lapatinib and Trastuzumab for HER2-Positive Breast Cancer: a Systematic Review and Meta-Analysis of Randomised Controlled Trials

JAMA Oncol

Brain Metastases in Newly Diagnosed Breast Cancer: A Population-Based Study

BMC Cancer

Development of a Test that Measures Real-Time HER2 Signaling Function in Live Breast Cancer Cell Lines and Primary Cells

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