Prescriber's Corner

A Review of the Bruton Tyrosine Kinase Inhibitors in B-Cell Malignancies

Donald C. Moore,(1) PharmD, BCPS, BCOP, DPLA, and Daniel Thompson,(2) PharmD

From (1)Atrium Health, Levine Cancer Institute, Department of Pharmacy, Concord, North Carolina; (2)Atrium Health Cabarrus, Department of Pharmacy, Concord, North Carolina

Authors’ disclosures of conflicts of interest are found at the end of this article.

Correspondence to: Donald C. Moore, PharmD, BCPS, BCOP, DPLA, Levine Cancer Institute, 100 Medical Park Drive, Concord, NC 28025. E-mail: donald.moore1@atriumhealth.org


J Adv Pract Oncol 2021;12(4):439–447 | https://doi.org/10.6004/jadpro.2021.12.4.8 | © 2021 Harborside™


  

ABSTRACT

The B-cell receptor signaling pathway plays an integral role in the proliferation and survival of malignant B cells. Targeting the B-cell receptor pathway via the inhibition of Bruton tyrosine kinase (BTK) has evolved the treatment of a variety of B-cell malignancies, including chronic lymphocytic leukemia, mantle cell lymphoma, marginal zone lymphoma, and Waldenström macroglobulinemia. Currently, there are three BTK inhibitors approved by the U.S. Food and Drug Administration: ibrutinib, acalabrutinib, and zanubrutinib. This article reviews the pharmacology, clinical efficacy, safety, dosing, drug-drug interactions, and implications for advanced practitioners of BTK inhibitors in the treatment of B-cell malignancies. 




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