Continuing Education

Continuing Education Information: CDK4/6 Inhibitors: Paving the Way for HR-Positive, HER2-Negative Early Breast Cancer

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CDK4/6 Inhibitors: Paving the Way for HR-Positive, HER2-Negative Early Breast Cancer

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This CPE/CNE/AAPA-certified supplement is provided by

Release date: 11/17/2021

  Estimated time of completion: 30 minutes

Expiration date: 11/16/2022

  Media: Certified journal article


This educational activity is intended for advanced practice clinicians, physician assistants, advanced practice nurses and pharmacists, oncology nurses, nurse navigators, and other healthcare professionals who are involved with the direct treatment and management of patients with HR+, HER2– breast cancer.


Endocrine therapy is currently the cornerstone of treatment for advanced hormone receptor–positive (HR+) breast cancer in both pre- and postmenopausal patients. However, not all advanced HR+ breast cancers respond to first-line endocrine therapy, and those that do respond eventually relapse. Agents that target critical pathways involved in resistance to endocrine therapy, such as cyclin-dependent kinase (CDK) 4/6 inhibitors, have been approved by the U.S. Food & Drug Administration (FDA) for the treatment of HR+/human epidermal growth factor receptor 2–negative (HER2–) advanced/metastatic breast cancer. Now, CDK4/6 inhibitors are being investigated for the treatment of early stage HR+, HER2– breast cancer added to adjuvant endocrine therapy, with the goal of preventing early recurrence and development of metastases.

This activity will review the latest emerging evidence for CDK4/6 inhibitors in the adjuvant setting for early breast cancer. Interprofessional perspectives and recommendations for improving adherence and side effect management will be featured.


At the conclusion of this activity, participants should be better able to:

  • Evaluate recent evidence supporting the use of CDK4/6 inhibitors for the adjuvant treatment of HR+, HER2– early breast cancer to prevent early disease recurrences and reduce the risk of distant metastases

  • Assess the efficacy of CDK4/6 inhibitors as adjuvant therapy in high-risk early breast cancer

  • Integrate strategies to promote and improve adherence in patients receiving oral CDK4/6 inhibitors for the treatment of breast cancer

  • Review recommendations for managing side effects that may occur with oral CDK4/6 inhibitors to prevent and reduce toxicities, treatment delays, and treatment discontinuation


Kristi K. Orbaugh, MSN, NP, AOCN®, Nurse Practitioner, Community Hospital Oncology Physicians, Zionsville, Indiana


Val R. Adams, PharmD, FCCP, BCOP, FHOPA, Associate Professor, Markey Cancer Center at the University of Kentucky, Lexington, Kentucky

Theresa W. Gillespie, PhD, MA, RN, FAAN, Professor, Department of Surgery and Department of Hematology & Medical Oncology, Emory University School of Medicine, Winship Cancer Institute, Atlanta, Georgia

This activity is supported by an educational grant from Lilly. For further information concerning Lilly grant funding visit


Accreditation Statement

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In support of improving patient care, AXIS Medical Education is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

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This activity was planned by and for the healthcare team, and learners will receive 0.5 Interprofessional Continuing Education (IPCE) credit for learning and change.

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Credit Designation for Physician Assistants

AXIS Medical Education has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 0.5 AAPA Category 1 CME credits. Approval is valid until 11/16/2022. PAs should only claim credit commensurate with the extent of their participation.

Credit Designation for Pharmacists

This knowledge-based activity is approved for 0.5 contact hours of continuing pharmacy education JA4008106-0000-21-077-H01-P.

Credit Designation for Nursing

AXIS Medical Education designates this continuing nursing education activity for 0.5 contact hours.

Learners are advised that accredited status does not imply endorsement by the provider or ANCC of any commercial products displayed in conjunction with an activity.

AXIS Contact Information

For information about the certification of this activity, please contact AXIS at

Fee Information

There is no fee for this educational activity.

Method of Participation and Request for Credit

To receive credit for this activity, participants must review the activity information including learning objectives and faculty/planner disclosures and actively participate in the educational activity. At the conclusion of your article participation, please visit Enter Access Code: 2266-BC

Upon successfully completing the post-test with a score of 75% or better and the post-activity evaluation, your certificate will be immediately available to you.

Disclosure of Conflict of Interest 

AXIS Medical Education requires faculty, instructors, authors, planners, directors, managers, reviewers, and other individuals who are in a position to control the content of this activity to disclose all real or apparent conflicts of interest they may have with ineligible companies. An ineligible entity is any organization whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. All relevant conflicts of interest are identified and mitigated prior to initiation of the planning phase for an activity. 

AXIS has mitigated and disclosed to learners all relevant conflicts of interest disclosed by staff, planners, faculty/authors, peer reviewers, or others in control of content for this activity. Disclosure of a relationship is not intended to suggest or condone bias in any presentation but is made to provide participants with information that might be of potential importance to their evaluation of a presentation or activity. Disclosure information for faculty, authors, course directors, planners, peer reviewers, and/or relevant staff is provided with this activity.

The faculty reported the following relevant financial relationships or relationships they have with ineligible companies of any amount during the past 24 months: Kristi K. Orbaugh, MSN, NP, AOCN®, reported a financial interest/relationship or affiliation in the form of Serve(d) as a speaker or a member of a speakers’ bureau for: Bristol-Myers Squibb Co; Pfizer, Inc; AstraZeneca Pharmaceuticals LP; Daiichi-Sankyo, Inc; Astellas Pharma US, Inc; Lilly USA; MorphoSys; Immunomedics, Inc; Gilead; and Coherus BioSciences. Val R. Adams, PharmD, FCCP, BCOP, FHOPA, reported a financial interest/relationship or affiliation in the form of Research grant: Bristol-Myers Squibb Co. Consultant: Regeneron Pharmaceuticals, Inc. Theresa W. Gillespie, PhD, MA, RN, FAAN, has no real or apparent conflicts of interest to report.

The following planners, directors, managers, reviewers Linda Gracie-King, MS; Jocelyn Timko, BS; Marilyn Haas-Haseman, PhD, RN, CNS, ANP-BC; and Adrienne N. Nedved, PharmD, MPA, BCOP hereby state that they do not have any financial relationships or relationships to products or devices with any ineligible company of any amount during the past 24 months.

Disclosure of Unlabeled Use

This educational activity may contain discussion of agents that are not approved for use by the FDA and/or investigational (“off-label”) uses of agents that are approved by the FDA. The planners of this activity do not recommend the use of any agent outside of its labeled indications. The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each agent for information on its approved indications, contraindications, warnings, and other, related information.


Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Read the Certified Article

How to Earn Credit

Click the button below to access the learning assessment and evaluation form online. Enter Access Code: 2266-BC.

Earn Credit

Statement of Credit: Participants who successfully complete this activity (including scoring of a minimum of 75% on the learning assessment) and complete and submit the evaluation form will be able to immediately download a statement of credit.

Pharmacists: Upon entry of your NABP e-profile number (usually 6–7 digits) and your date-of-birth in MMDD format, your record will automatically upload to CPE Monitor.

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