Review Article

Optimizing Use of Newly Approved Agents for Acute Myeloid Leukemia

Nancy M. Nix, PharmD, BCPS, BCOP, and Allyson Price, MPAS, PA-C

Ballad Health, Johnson City, Tennessee, and MD Anderson Cancer Center, Houston, Texas

Authors’ disclosures of conflicts of interest are found at the end of this article.

Allyson Price, MPAS, PA-C, 1515 Holcombe Boulevard, Houston, TX 77030. E-mail:

J Adv Pract Oncol 2019;10(suppl 4):9–18 | | © 2019 Harborside™




Until recently, treatment advances in acute myeloid leukemia (AML) had been slow since the 1970s. However, in the past few years, as the understanding of the pathophysiology of AML has advanced, numerous treatments have been approved by the U.S. Food & Drug Administration. This article reviews the mechanisms of action, indications, and clinical trial details for eight novel agents, as well as the current discussions surrounding monitoring minimal residual disease.

This article is a part of a JADPRO certified supplement, Optimizing Treatment and Improving Outcomes for Patients With Acute Myeloid Leukemia: A Guide for Advanced Practitioners

Table of Contents

  1. Acute Myeloid Leukemia: An Ever-Changing Disease
  2. Optimizing Use of Newly Approved Agents for Acute Myeloid Leukemia (current article)
  3. The Role of the Advanced Practitioner in Enhancing Outcomes
  4. Appendix: Key Information on Newly Approved AML Drugs

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