Downregulation of GATA1 Drives Impaired Hematopoiesis in Primary Myelofibrosis
In a recent study on primary myelofibrosis, investigators noted that reduced GATA1 expression and impaired differentiation were limited to megakaryocytes, consistent with a pro-proliferative effect of a GATA1 deficiency on this lineage. Importantly, they found that expression of GATA1 effectively rescued maturation of primary myelofibrosis megakaryocytes. Together, these results suggest that ribosomal deficiency contributes to impaired megakaryopoiesis in myeloproliferative neoplasms.
J Clin Invest
In The News
Oncology Nurse Advisor
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American Journal of Managed Care
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In The Literature
Blood (ASH Abstract)
A Phase 2 Study of the Safety and Efficacy of INCB050465, a Selective PI3Kδ Inhibitor, in Combination With Ruxolitinib in Patients with Myelofibrosis
Blood (ASH Abstract)
Independent Association of Male Sex With Presentation and Clinical Outcomes in Myeloproliferative Neoplasms
American Journal of Hematology
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European Journal of Haematology