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Cutaneous Myeloid Dendritic Cell Dyscrasia: A Cutaneous Clonal Monocytosis Associated with Chronic Myeloproliferative Disorders and Peripheral Blood Monocytosis

In a recent study, 11 patients with a diagnosis of cutaneous mDC dyscrasia were evaluated. Each patient had a prior or subsequent diagnosis of an abnormal bone marrow biopsy that included myelodysplastic syndrome, myelofibrosis, chronic myelomonocytic leukemia, and acute myelogenous leukemia. The authors noted that while the myeloid DC (mDC) is recognized in the immunology literature, it does not have a well-defined neoplastic cutaneous counterpart. Thus, the propose the term cutaneous mDC cell dyscrasia for distinctive infiltrates of differentiated mDCs reflective of underlying myeloproliferative disease.

 Ann Diagn Pathol

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