T-DM1 Offers Similar PFS, More Tolerable in Advanced HER2-Positive Breast Cancer

The antibody-drug conjugate trastuzumab emtansine (T-DM1) showed non-inferior—but not superior—efficacy to trastuzumab plus a taxane in women with advanced HER2-positive breast cancer, according to a phase III trial. T-DM1 alone and in combination with pertuzumab showed similar results.


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Perspectives on the Collaborative Management of HER2-Positive Breast Cancer

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In The News

The ASCO Post

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Age and Subtype Impact Outcomes More Than Surgical Extent in Breast Cancer

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Neoadjuvant Therapy Fundamental in Triple-Negative and HER2-Positive Breast Cancer

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Kisqali Approved by FDA to Treat Hormone-Receptor-Positive, Advanced-Stage Disease

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In The Literature

JAMA Oncol

Adjuvant Capecitabine in Combination With Docetaxel, Epirubicin, and Cyclophosphamide for Early Breast Cancer: The Randomized Clinical FinXX Trial

Eur J Cancer

Long-term Outcome of the REMAGUS 02 Trial, a Multicenter Randomised Phase II Trial in Locally Advanced Breast Cancer Patients Treated With Neoadjuvant Chemotherapy With or Without Celecoxib or Trastuzumab According to HER2 Status

BMJ Open

Efficacy and Safety of Lapatinib and Trastuzumab for HER2-Positive Breast Cancer: a Systematic Review and Meta-Analysis of Randomised Controlled Trials

JAMA Oncol

Brain Metastases in Newly Diagnosed Breast Cancer: A Population-Based Study

BMC Cancer

Development of a Test that Measures Real-Time HER2 Signaling Function in Live Breast Cancer Cell Lines and Primary Cells

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