In HER2-Negative Breast Cancer, Brain Mets Are HER2-Positive 20% of the Time

The finding that a patient with HER2-negative breast cancer can have brain metastases that are HER2-positive warrants "immediate clinical attention," say researchers who found this was the case in one in five patients in a small, unique study. Immediate steps are needed because such patients could benefit from a HER-targeted therapy but will not receive one because they tested HER2 negative for the primary breast cancer, they point out.