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Understanding the Mechanism of Action for Chimeric Antigen Receptor (CAR) Therapy

Edward Stadtmauer, MD
Abramson Cancer Center, University of Pennsylvania

Patricia A. Mangan, RN, MSN, APRN-BC
Abramson Cancer Center, University of Pennsylvania

Adoptive immunotherapy involves engineering the patient’s own T-cells by artificially equipping them with chimeric antigen receptors (CARs) which then enable them to bind to certain proteins on the surface of malignant cells. Referred to as CAR-T cell therapy, this form of treatment has had stunning results in acute lymphoblastic leukemia (ALL) and lymphoma. Cytokine release syndrome (CRS), which can be severe and involve multi-organ failure, is a major potential toxicity. This program will provide advanced practitioners with cutting edge information about adoptive CAR-T cell immunotherapy, mechanism of action, unique and potentially serious side effects, and how to monitor for and manage CRS.


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