Review Article

Idelalisib: Practical Tools for Identifying and Managing Adverse Events in Clinical Practice

Nancy Driscoll, PA-C

North Shore-LIJ CLL Research and Treatment Center, New Hyde Park, New York

Author’s disclosures of potential conflicts of interest are found at the end of this article.

Nancy Driscoll, PA-C, Genentech-BioOncology, 1 DNA Way, South San Francisco, CA 90480. E-mail: driscoll.nancy@gene.com


J Adv Pract Oncol 2016;7:604–613 | doi: 10.6004/jadpro.2016.7.6.3 | © 2016 Harborside Press®


  

ABSTRACT

Abstract

Idelalisib is a first-in-class oral selective inhibitor of phosphatidylinositol 3-kinase delta, which is selectively expressed in hematopoietic cells, where it is critical to B-cell receptor signaling and B-cell development and function. Idelalisib is approved in the United States for the treatment of relapsed chronic lymphocytic leukemia (CLL; in combination with rituximab), relapsed follicular lymphoma (FL), and small lymphocytic lymphoma (SLL) and in the European Union for the treatment of CLL (in combination with rituximab). Approval was based on clinical activity in a phase II trial in indolent non-Hodgkin lymphoma and a phase III trial in CLL. Because idelalisib is a relatively new treatment option for patients with relapsed CLL, SLL, and FL, with a safety profile distinct from other agents, it is important for advanced practitioners (APs) to familiarize themselves with the adverse event (AE) profile and educate their patients as well. As active members of the oncology care team, APs can play a vital role in optimizing outcomes in patients receiving idelalisib therapy. This review will familiarize APs with the AE profile of idelalisib and provide practical information about the identification and management of AEs associated with idelalisib therapy.




For access to the full length article, please sign in.

Section Seperator
ADVERTISEMENT
Section Seperator
ADVERTISEMENT
Section Seperator
ADVERTISEMENT
Section Seperator
Copyright © 2016 Harborside Press, LLC All rights reserved.                Home | Current Issue | Previous Issue | Submissions | About JADPRO | Advertising | Privacy Policy | Contact
Copyright Notice/Disclaimer
Bot trap - Don't go here
click me