Review Article

Ceftazidime for Neutropenic Fevers: Is It Still an Appropriate Choice?

Ellen Bethany Napier, CRNP

From Jefferson University Physicians, Philadelphia, Pennsylvania

The author has no conflicts of interest to disclose.

Correspondence to: Ellen Bethany Napier, CRNP, Jefferson University Physicians, Medical Oncology, 925 Chestnut Street, Suite 220A, Philadelphia, PA 19107. E-mail: ellen.napier@jefferson.edu


J Adv Pract Oncol 2013;4:394–401 | DOI: 10.6004/jadpro.2013.4.6.2 | © 2013 Harborside Press®


  

ABSTRACT

Infection continues to rank as a primary cause of treatment-related mortality in patients with cancer. For patients with neutropenic fevers, immediate empiric treatment with antibiotics is standard care. However, which specific antibiotic is best for initial treatment of high-risk patients has been much debated without consensus. Many major health centers use intravenous ceftazidime as first-line therapy for these patients. Yet updates to guidelines published by the Infectious Diseases Society of America and the National Comprehensive Cancer Network suggest that ceftazidime may no longer be an optimal choice. This article reviews the literature regarding ceftazidime therapy for the treatment of high-risk neutropenic patients with fevers. This critical analysis of existing research reveals significant pharmacologic, physiologic, social, and financial implications, and recommendations for further studies are made.




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