Review Article

Multiple Myeloma: Cast Nephropathy, VTE, and Neurologic Complications

Ellen Sullivan, MNSC, APN, ACNP-BC, OCN®, Lisa C. Smith, MSN, FNP, AOCN®, and Angela M. Falco, RN, MS/MPH, ANP-C

From Celgene Corporation (all authors are clinical nurse consultants)

Ellen Sullivan, Lisa C. Smith, and Angela M. Falco are employees of Celgene Corporation.

Correspondence to: Ellen Sullivan, MNSC, APN, ACNP-BC, OCN®, 4611 Locust, North Little Rock, AR 72116. E-mail: esullivan@celgene.com


J Adv Pract Oncol 2013;4:37–46 | DOI: 10.6004/jadpro.2013.4.1.4 | © 2013 Harborside Press®


  

ABSTRACT

Multiple myeloma accounts for approximately 1% of neoplastic diseases and 13% of hematologic cancers. Complications often associated with MM include neurologic and hematologic issues, infections, renal insufficiency, and bone involvement. It is crucial for advanced practice professionals caring for myeloma patients to assess patients accurately, be keenly aware of possible associated complications, and be familiar with appropriate interventions to prevent further injury. This article will provide an overview of MM-related renal insufficiency, with a focus on cast nephropathy, venous thromboembolism, and neurologic complications along with various causes and treatment options; a future article will address additional complications associated with MM.




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